| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropeptide Y receptor type 1 |
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| Ligand | BDBM50142763 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_143685 |
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| IC50 | 1.4±n/a nM |
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| Citation |  Sato, N; Shibata, T; Jitsuoka, M; Ohno, T; Takahashi, T; Hirohashi, T; Kanno, T; Iwaasa, H; Kanatani, A; Fukami, T Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists. Bioorg Med Chem Lett14:1761-4 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropeptide Y receptor type 1 |
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| Name: | Neuropeptide Y receptor type 1 |
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| Synonyms: | NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44399.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | NPY-Y1 NPY1R HUMAN::P25929 |
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| Residue: | 384 |
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| Sequence: | MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
KTSLKQASPVAFKKINNNDDNEKI
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| BDBM50142763 |
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| n/a |
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| Name | BDBM50142763 |
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| Synonyms: | CHEMBL50184 | [3-Chloro-5-({6-[2-(5-ethyl-4-methyl-thiazol-2-yl)-ethyl]-4-morpholin-4-yl-pyridin-2-ylamino}-methyl)-phenyl]-carbamic acid isopropyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36ClN5O3S |
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| Mol. Mass. | 558.135 |
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| SMILES | CCc1sc(CCc2cc(cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)N2CCOCC2)nc1C |
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| Structure | 
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