Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM50577755

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2130818 (CHEMBL4840247)

EC50

0.023000±n/a nM

Citation

Pi, Z; Johnson, JA; Meng, W; Phillips, M; Schumacher, WA; Bostwick, JS; Gargalovic, PS; Onorato, JM; Generaux, CN; Wang, T; He, Y; Gordon, DA; Wexler, RR; Finlay, HJ Identification of 6-Hydroxypyrimidin-4(1 ACS Med Chem Lett12:1766-1772 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50577755

n/a

Name

BDBM50577755

Synonyms:

CHEMBL4861895

Type

Small organic molecule

Emp. Form.

C25H26N4O6

Mol. Mass.

478.4971

SMILES

CCOCc1[nH]c(=O)c(-c2nnc(Cc3ccc(C)cn3)o2)c(O)c1-c1c(OC)cccc1OC |(56.32,-36.8,;57.65,-37.57,;58.99,-36.8,;60.32,-37.56,;61.65,-36.79,;61.65,-35.25,;62.99,-34.48,;62.99,-32.94,;64.32,-35.25,;65.66,-34.48,;67.06,-35.1,;68.09,-33.96,;67.32,-32.63,;67.95,-31.22,;69.48,-31.06,;70.1,-29.66,;71.62,-29.49,;72.54,-30.74,;74.07,-30.58,;71.91,-32.15,;70.38,-32.31,;65.81,-32.95,;64.32,-36.78,;65.66,-37.55,;62.99,-37.55,;63,-39.08,;64.33,-39.85,;65.66,-39.07,;67,-39.84,;64.34,-41.4,;63,-42.17,;61.66,-41.4,;61.67,-39.85,;60.33,-39.08,;59,-39.85,)|

Structure