| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase UHRF1 |
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| Ligand | BDBM50578341 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2132632 (CHEMBL4842147) |
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| Kd | >111000±n/a nM |
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| Citation |  Kori, S; Shibahashi, Y; Ekimoto, T; Nishiyama, A; Yoshimi, S; Yamaguchi, K; Nagatoishi, S; Ohta, M; Tsumoto, K; Nakanishi, M; Defossez, PA; Ikeguchi, M; Arita, K Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1. Bioorg Med Chem52:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase UHRF1 |
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| Name: | E3 ubiquitin-protein ligase UHRF1 |
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| Synonyms: | 6.3.2.- | E3 ubiquitin-protein ligase (UHRF1) | E3 ubiquitin-protein ligase UHRF1 | HuNp95 | ICBP90 | Inverted CCAAT box-binding protein of 90 kDa | NP95 | Nuclear protein 95 | Nuclear zinc finger protein Np95 | RING finger protein 106 | RNF106 | Transcription factor ICBP90 | UHRF1 | UHRF1_HUMAN | Ubiquitin-like PHD and RING finger domain-containing protein 1 | Ubiquitin-like-containing PHD and RING finger domains protein 1 | hNp95 | hUHRF1 |
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| Type: | Protein |
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| Mol. Mass.: | 89822.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 793 |
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| Sequence: | MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFYRGKQMEDGHTLFD
YEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKSSTHGEAAAETDSR
PADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEPCSSTSRPALEE
DVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYD
AEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGSPMVDNPMRRKSGP
SCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDPPLSSVPSEDEWYC
PECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRTKECTIVPSNHYGP
IPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDHGNFFTYTG
SGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDWRSGKPVRVVRNVK
GGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEPGPWTKEGKDRIKK
LGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKWKRKSAGGGPSRAG
SPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPASGSPFQLFLSKVEE
TFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLGRSYAMQVNQPLQT
VLNQLFPGYGNGR
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| BDBM50578341 |
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| n/a |
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| Name | BDBM50578341 |
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| Synonyms: | CHEMBL4860378 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H10N2 |
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| Mol. Mass. | 122.1677 |
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| SMILES | Cc1cc(C)c(N)cn1 |
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| Structure | 
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