| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 5A, mitochondrial |
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| Ligand | BDBM50580100 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2146934 (CHEMBL5031280) |
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| Ki | 58±n/a nM |
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| Citation |  Plyasova, AA; Berrino, E; Khan, II; Veselovsky, AV; Pokrovsky, VS; Angeli, A; Ferraroni, M; Supuran, CT; Pokrovskaya, MV; Alexandrova, SS; Gladilina, YA; Sokolov, NN; Hilal, A; Carta, F; Zhdanov, DD Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors. J Med Chem64:11432-11444 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 5A, mitochondrial |
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| Name: | Carbonic anhydrase 5A, mitochondrial |
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| Synonyms: | CA-VA | CA5 | CA5A | CAH5A_HUMAN | Carbonate dehydratase VA | Carbonic Anhydrase VA | Carbonic anhydrase 5A (CA VA) | Carbonic anhydrase 5A, mitochondrial | Carbonic anhydrase 5A, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VA (CA VA) |
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| Type: | Enzyme |
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| Mol. Mass.: | 34755.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human (cloned) isozyme |
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| Residue: | 305 |
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| Sequence: | MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPG
GTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPL
ENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVI
GVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLT
ESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATN
EGTRS
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| BDBM50580100 |
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| n/a |
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| Name | BDBM50580100 |
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| Synonyms: | CHEMBL5089227 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21N5O7 |
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| Mol. Mass. | 467.4314 |
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| SMILES | Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(COc3ccc4oc(=O)ccc4c3)nn2)c(=O)[nH]c1=O |r| |
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| Structure | 
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