Reaction Details |
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Target | Mitogen-activated protein kinase kinase kinase 7 |
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Ligand | BDBM50582270 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2153908 (CHEMBL5038455) |
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IC50 | 450±n/a nM |
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Citation | Chen, Y; Singh, R; Lin, N; Taylor, V; Masuda, ES; Payan, DG Discovery of 5-Aryl-2,4-diaminopyrimidine Compounds as Potent and Selective IRAK4 Inhibitors. ACS Med Chem Lett13:714-719 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase kinase kinase 7 |
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Name: | Mitogen-activated protein kinase kinase kinase 7 |
Synonyms: | M3K7_HUMAN | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | TAK1 | TAK1/TAB1 | TGF-beta-activated kinase 1 | Transforming growth factor-beta-activated kinase 1 (TAK1) |
Type: | Protein |
Mol. Mass.: | 67199.89 |
Organism: | Homo sapiens (Human) |
Description: | O43318 |
Residue: | 606 |
Sequence: | MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN
ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI
ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ
KRQGTS
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BDBM50582270 |
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n/a |
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Name | BDBM50582270 |
Synonyms: | CHEMBL5084495 |
Type | Small organic molecule |
Emp. Form. | C27H28FN7O2 |
Mol. Mass. | 501.5553 |
SMILES | [H][C@@]12C[C@@]([H])(C=C1)[C@@H]([C@@H]2Nc1nc(Nc2ccc(nc2)N2CCOCC2)ncc1-c1cccc(F)c1)C(N)=O |r,c:5| |
Structure |
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