| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 9 |
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| Ligand | BDBM50583749 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2158057 (CHEMBL5042807) |
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| IC50 | 3027±n/a nM |
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| Citation |  Weber, C; Sipos, M; Paczal, A; Balint, B; Kun, V; Foloppe, N; Dokurno, P; Massey, AJ; Walmsley, DL; Hubbard, RE; Murray, J; Benwell, K; Edmonds, T; Demarles, D; Bruno, A; Burbridge, M; Cruzalegui, F; Kotschy, A Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J Med Chem64:6745-6764 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 9 |
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| Name: | Cyclin-dependent kinase 9 |
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| Synonyms: | C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 42789.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 372 |
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| Sequence: | MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP
ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK
FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS
QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP
ATTNQTEFERVF
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| BDBM50583749 |
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| n/a |
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| Name | BDBM50583749 |
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| Synonyms: | CHEMBL5089294 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20N6O |
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| Mol. Mass. | 312.3696 |
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| SMILES | COCCCn1c(C)nc2ccc(nc12)-c1cc(N)nc(N)c1 |
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| Structure | 
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