| Reaction Details |
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 | Report a problem with these data |
| Target | Early activation antigen CD69 |
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| Ligand | BDBM50583945 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2158455 (CHEMBL5043205) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Hopkins, BT; Bame, E; Bajrami, B; Black, C; Bohnert, T; Boiselle, C; Burdette, D; Burns, JC; Delva, L; Donaldson, D; Grater, R; Gu, C; Hoemberger, M; Johnson, J; Kapadnis, S; King, K; Lulla, M; Ma, B; Marx, I; Magee, T; Meissner, R; Metrick, CM; Mingueneau, M; Murugan, P; Otipoby, KL; Polack, E; Poreci, U; Prince, R; Roach, AM; Rowbottom, C; Santoro, JC; Schroeder, P; Tang, H; Tien, E; Zhang, F; Lyssikatos, J Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis. J Med Chem65:1206-1224 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Early activation antigen CD69 |
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| Name: | Early activation antigen CD69 |
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| Synonyms: | AIM | Activation inducer molecule | BL-AC/P26 | C-type lectin domain family 2 member C | CD69 | CD69_HUMAN | CD_antigen=CD69 | CLEC2C | EA1 | Early T-cell activation antigen p60 | Early activation antigen CD69 | GP32/28 | Leukocyte surface antigen Leu-23 | MLR-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22559.65 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_109097 |
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| Residue: | 199 |
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| Sequence: | MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQVPVLCAVMNVVFITILIIALIA
LSVGQYNCPGQYTFSMPSDSHVSSCSEDWVGYQRKCYFISTVKRSWTSAQNACSEHGATL
AVIDSEKDMNFLKRYAGREEHWVGLKKEPGHPWKWSNGKEFNNWFNVTGSDKCVFLKNTE
VSSMECEKNLYWICNKPYK
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| BDBM50583945 |
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| n/a |
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| Name | BDBM50583945 |
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| Synonyms: | CHEMBL5080861 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N8O2 |
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| Mol. Mass. | 486.5688 |
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| SMILES | Cn1cc(Nc2nccc(n2)-c2ccc3[C@@H](CCCCc3c2)NC(=O)c2noc(n2)C(C)(C)C)cn1 |r| |
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| Structure | 
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