| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
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| Ligand | BDBM50584984 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2161055 (CHEMBL5045805) |
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| IC50 | <50119±n/a nM |
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| Citation |  Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase ? Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode. J Med Chem65:3359-3370 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
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| Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
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| Synonyms: | 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha | 2.7.1.149 | Diphosphoinositide kinase 2-alpha | PI(5)P 4-kinase type II alpha | PI42A_HUMAN | PI5P4KA | PIP4K2A | PIP4KII-alpha | PIP5K2 | PIP5K2A | PIP5KIII | Phosphatidylinositol 5-phosphate 4-kinase type II alpha | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha | PtdIns(4)P-5-kinase B isoform | PtdIns(4)P-5-kinase C isoform | PtdIns(5)P-4-kinase isoform 2-alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46228.59 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_104274 |
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| Residue: | 406 |
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| Sequence: | MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVM
LMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSA
PLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLG
MYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFIN
EGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEE
EGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDI
LTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
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| BDBM50584984 |
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| n/a |
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| Name | BDBM50584984 |
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| Synonyms: | CHEMBL5079093 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15F3N4 |
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| Mol. Mass. | 380.3658 |
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| SMILES | FC(F)(F)c1ccccc1-c1nc(NCc2ccccn2)c2ccccc2n1 |
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| Structure | 
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