| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Sgk1 |
|---|
| Ligand | BDBM50585045 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2161409 (CHEMBL5046159) |
|---|
| IC50 | 212±n/a nM |
|---|
| Citation |  Powell, CE; Hatcher, JM; Jiang, J; Vatsan, PS; Che, J; Gray, NS Selective Macrocyclic Inhibitors of DYRK1A/B. ACS Med Chem Lett13:577-585 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Sgk1 |
|---|
| Name: | Serine/threonine-protein kinase Sgk1 |
|---|
| Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) |
|---|
| Type: | Other Protein Type |
|---|
| Mol. Mass.: | 48954.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. |
|---|
| Residue: | 431 |
|---|
| Sequence: | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
|
|
|
|---|
| BDBM50585045 |
|---|
| n/a |
|---|
| Name | BDBM50585045 |
|---|
| Synonyms: | CHEMBL5093741 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19F3N8O |
|---|
| Mol. Mass. | 468.4345 |
|---|
| SMILES | CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2 |
|---|
| Structure | 
|
|---|
Search and Browse
