| Reaction Details |
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 | Report a problem with these data |
| Target | N-acetyltransferase Eis |
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| Ligand | BDBM50019949 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2195999 (CHEMBL5108515) |
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| IC50 | 850±n/a nM |
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| Citation |  Punetha, A; Green, KD; Garzan, A; Thamban Chandrika, N; Willby, MJ; Pang, AH; Hou, C; Holbrook, SYL; Krieger, K; Posey, JE; Parish, T; Tsodikov, OV; Garneau-Tsodikova, S Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from RSC Med Chem12:1894-1909 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-acetyltransferase Eis |
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| Name: | N-acetyltransferase Eis |
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| Synonyms: | Aminoglycoside N-acetyltransferase | EIS_MYCTU | Enhanced intracellular survival protein | N-acetyltransferase Eis | Protein-lysine N-acetyltransferase | eis |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43803.37 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | ChEMBL_116995 |
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| Residue: | 402 |
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| Sequence: | MTVTLCSPTEDDWPGMFLLAAASFTDFIGPESATAWRTLVPTDGAVVVRDGAGPGSEVVG
MALYMDLRLTVPGEVVLPTAGLSFVAVAPTHRRRGLLRAMCAELHRRIADSGYPVAALHA
SEGGIYGRFGYGPATTLHELTVDRRFARFHADAPGGGLGGSSVRLVRPTEHRGEFEAIYE
RWRQQVPGGLLRPQVLWDELLAECKAAPGGDRESFALLHPDGYALYRVDRTDLKLARVSE
LRAVTADAHCALWRALIGLDSMERISIITHPQDPLPHLLTDTRLARTTWRQDGLWLRIMN
VPAALEARGYAHEVGEFSTVLEVSDGGRFALKIGDGRARCTPTDAAAEIEMDRDVLGSLY
LGAHRASTLAAANRLRTKDSQLLRRLDAAFASDVPVQTAFEF
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| BDBM50019949 |
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| n/a |
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| Name | BDBM50019949 |
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| Synonyms: | 1-(4-Fluoro-phenyl)-4-(4-hydroxy-4-phenyl-piperidin-1-yl)-butan-1-one | CHEMBL54206 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24FNO2 |
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| Mol. Mass. | 341.4192 |
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| SMILES | OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccccc1 |
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| Structure | 
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