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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Alpha-2A adrenergic receptor | ||
| Ligand | BDBM50166562 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_306656 (CHEMBL831429) | ||
| IC50 | 140±n/a nM | ||
| Citation |  Kanuma, K; Omodera, K; Nishiguchi, M; Funakoshi, T; Chaki, S; Semple, G; Tran, TA; Kramer, B; Hsu, D; Casper, M; Thomsen, B; Beeley, N; Sekiguchi, Y Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett15:2565-9 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Alpha-2A adrenergic receptor | |||
| Name: | Alpha-2A adrenergic receptor | ||
| Synonyms: | ADA2A_HUMAN | ADRA2A | ADRA2R | ADRAR | Adrenergic alpha2A | Adrenergic receptor alpha | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | alpha-2A adrenergic receptor [Homo sapiens] | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 48979.91 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08913 | ||
| Residue: | 465 | ||
| Sequence: |
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| BDBM50166562 | |||
| n/a | |||
| Name | BDBM50166562 | ||
| Synonyms: | 4-Bromo-N-[4-(quinazolin-2-ylaminomethyl)-cyclohexylmethyl]-2-trifluoromethoxy-benzenesulfonamide | CHEMBL425012 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24BrF3N4O3S | ||
| Mol. Mass. | 573.426 | ||
| SMILES | FC(F)(F)Oc1cc(Br)ccc1S(=O)(=O)NCC1CCC(CNc2ncc3ccccc3n2)CC1 |(6.79,-3.41,;8.33,-3.41,;9.87,-3.41,;8.33,-4.95,;8.38,-1.87,;9.73,-1.15,;11.04,-1.96,;12.39,-1.22,;13.71,-2.03,;12.44,.33,;11.13,1.12,;9.78,.39,;8.47,1.2,;9.22,2.53,;7.37,.11,;7.14,1.97,;5.81,1.21,;4.48,2,;3.13,1.23,;1.8,2.01,;1.83,3.54,;.5,4.31,;-.84,3.56,;-2.16,4.31,;-2.17,5.87,;-3.52,6.65,;-4.85,5.87,;-6.2,6.62,;-7.53,5.87,;-7.53,4.31,;-6.2,3.54,;-4.85,4.31,;-3.51,3.54,;3.16,4.31,;4.49,3.54,)| | ||
| Structure | 
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