Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Melanin-concentrating hormone receptor 1 | ||
Ligand | BDBM50166562 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_317594 (CHEMBL825590) | ||
IC50 | 2900±n/a nM | ||
Citation | Kanuma, K; Omodera, K; Nishiguchi, M; Funakoshi, T; Chaki, S; Semple, G; Tran, TA; Kramer, B; Hsu, D; Casper, M; Thomsen, B; Beeley, N; Sekiguchi, Y Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett15:2565-9 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Melanin-concentrating hormone receptor 1 | |||
Name: | Melanin-concentrating hormone receptor 1 | ||
Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 45976.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. | ||
Residue: | 422 | ||
Sequence: |
| ||
BDBM50166562 | |||
n/a | |||
Name | BDBM50166562 | ||
Synonyms: | 4-Bromo-N-[4-(quinazolin-2-ylaminomethyl)-cyclohexylmethyl]-2-trifluoromethoxy-benzenesulfonamide | CHEMBL425012 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H24BrF3N4O3S | ||
Mol. Mass. | 573.426 | ||
SMILES | FC(F)(F)Oc1cc(Br)ccc1S(=O)(=O)NCC1CCC(CNc2ncc3ccccc3n2)CC1 |(6.79,-3.41,;8.33,-3.41,;9.87,-3.41,;8.33,-4.95,;8.38,-1.87,;9.73,-1.15,;11.04,-1.96,;12.39,-1.22,;13.71,-2.03,;12.44,.33,;11.13,1.12,;9.78,.39,;8.47,1.2,;9.22,2.53,;7.37,.11,;7.14,1.97,;5.81,1.21,;4.48,2,;3.13,1.23,;1.8,2.01,;1.83,3.54,;.5,4.31,;-.84,3.56,;-2.16,4.31,;-2.17,5.87,;-3.52,6.65,;-4.85,5.87,;-6.2,6.62,;-7.53,5.87,;-7.53,4.31,;-6.2,3.54,;-4.85,4.31,;-3.51,3.54,;3.16,4.31,;4.49,3.54,)| | ||
Structure |