Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50167661 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_306492 (CHEMBL827995) |
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IC50 | 14000±n/a nM |
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Citation | Pfefferkorn, JA; Nugent, R; Gross, RJ; Greene, M; Mitchell, MA; Reding, MT; Funk, LA; Anderson, R; Wells, PA; Shelly, JA; Anstadt, R; Finzel, BC; Harris, MS; Kilkuskie, RE; Kopta, LA; Schwende, FJ Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid. Bioorg Med Chem Lett15:2812-8 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
Type: | Protein |
Mol. Mass.: | 25173.95 |
Organism: | Hepatitis C virus |
Description: | Q8JXU8 |
Residue: | 229 |
Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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BDBM50167661 |
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n/a |
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Name | BDBM50167661 |
Synonyms: | (Z)-3-[4-(4-Amino-2-trifluoromethyl-phenoxy)-phenyl]-2-(3-cyclopentyl-propionylamino)-acrylic acid | CHEMBL192112 |
Type | Small organic molecule |
Emp. Form. | C24H25F3N2O4 |
Mol. Mass. | 462.4615 |
SMILES | Nc1ccc(Oc2ccc(\C=C(/NC(=O)CCC3CCCC3)C(O)=O)cc2)c(c1)C(F)(F)F |
Structure |
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