Reaction Details | |||
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Target | Protein mono-ADP-ribosyltransferase PARP14 | ||
Ligand | BDBM434315 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2211539 (CHEMBL5124488) | ||
IC50 | 3.0±n/a nM | ||
Citation | Nizi, MG; Maksimainen, MM; Lehtiö, L; Tabarrini, O Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules. J Med Chem65:7532-7560 (2022) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein mono-ADP-ribosyltransferase PARP14 | |||
Name: | Protein mono-ADP-ribosyltransferase PARP14 | ||
Synonyms: | (ARTD8 or PARP14) | (ARTD8 or PARP14, Y1660L) | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 8 | ARTD8 | B aggressive lymphoma protein 2 | BAL2 | BAL2Â | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD8 or PARP14, Y1660L) | KIAA1268 | KIAA1268 GN | KIAA1268 GN | PAR14_HUMAN | PARP-14 | PARP14 | Poly [ADP-ribose] polymerase 14 | Synonyms=BAL2 | ||
Type: | n/a | ||
Mol. Mass.: | 202812.41 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q460N5 | ||
Residue: | 1801 | ||
Sequence: |
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BDBM434315 | |||
n/a | |||
Name | BDBM434315 | ||
Synonyms: | US10562891, Example 235 | US11008308, Example 235 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H23FN2O3S | ||
Mol. Mass. | 378.461 | ||
SMILES | O[C@H]1CC[C@@H](CC1)SCc1nc2cc(OCC3CC3)cc(F)c2c(=O)[nH]1 |r,wU:4.7,wD:1.0,(8.77,-4.62,;7.44,-3.85,;7.44,-2.31,;6.1,-1.54,;4.77,-2.31,;4.77,-3.85,;6.1,-4.62,;3.44,-1.54,;3.44,,;2.1,.77,;.77,,;-.56,.77,;-1.9,,;-3.23,.77,;-4.56,,;-5.9,.77,;-7.23,,;-8.77,,;-8,-1.33,;-3.23,2.31,;-1.9,3.08,;-1.9,4.62,;-.56,2.31,;.77,3.08,;.77,4.62,;2.1,2.31,)| | ||
Structure |