| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 1 |
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| Ligand | BDBM50594499 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2213098 (CHEMBL5126047) |
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| IC50 | <100000±n/a nM |
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| Citation |  Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A Unveiling the Structure-Activity Relationships at the Orthosteric Binding Site of P2X Ion Channels: The Route to Selectivity. J Med Chem65:11291-11308 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 1 |
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| Name: | P2X purinoceptor 1 |
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| Synonyms: | ATP receptor | P2RX1 | P2RX1_HUMAN | P2X1 | Purinergic receptor | Purinergic, P2X |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44992.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purinergic, P2X 0 HUMAN::P51575 |
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| Residue: | 399 |
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| Sequence: | MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSG
LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEH
PEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLR
EAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESG
QNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVEN
GTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKR
HYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS
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| BDBM50594499 |
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| n/a |
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| Name | BDBM50594499 |
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| Synonyms: | CHEMBL5171786 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H24N5O13P3 |
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| Mol. Mass. | 563.2873 |
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| SMILES | CCCCNc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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