Reaction Details |
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Target | Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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Ligand | BDBM50594787 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2214235 (CHEMBL5127367) |
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IC50 | >10000±n/a nM |
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Citation | Tahtouh, T; Durieu, E; Villiers, B; Bruyère, C; Nguyen, TL; Fant, X; Ahn, KH; Khurana, L; Deau, E; Lindberg, MF; Sévère, E; Miege, F; Roche, D; Limanton, E; L'Helgoual'ch, JM; Burgy, G; Guiheneuf, S; Herault, Y; Kendall, DA; Carreaux, F; Bazureau, JP; Meijer, L Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. J Med Chem65:1396-1417 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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Name: | Glycogen synthase kinase-3 beta/[Tau protein] kinase |
Synonyms: | Glycogen synthase kinase-3 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 2105817 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Glycogen synthase kinase-3 beta |
Synonyms: | Glycogen synthase kinase 3 beta | Glycogen synthase kinase-3 |
Type: | PROTEIN |
Mol. Mass.: | 46774.42 |
Organism: | Sus scrofa |
Description: | ChEMBL_939732 |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTMVATPGQGPDRPQEVSYTDAK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQTNNTASASASNST
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Component 2 |
Name: | [Tau protein] kinase |
Synonyms: | GSK3A | Glycogen synthase kinase 3 alpha |
Type: | PROTEIN |
Mol. Mass.: | 51010.29 |
Organism: | Sus scrofa |
Description: | ChEMBL_117799 |
Residue: | 483 |
Sequence: | MSGGAPSGGGPGGSGRARTSSFAEHGGGGGGSGGGPGGSASGPGGGGGGKPSVGAMGGGV
GASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLADTRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPIIYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATGYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAITLCSSLLEYTPSSRLSPLEACAHNFFDELRCPGTQLPNNRPLP
PLFNFSPGELTIQPSLNAILIPPHLRSPAGTASLTSSSQALSETPTGPDWQSTDATTPLT
NSS
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BDBM50594787 |
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n/a |
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Name | BDBM50594787 |
Synonyms: | CHEMBL5172170 |
Type | Small organic molecule |
Emp. Form. | C19H17N3O3 |
Mol. Mass. | 335.3566 |
SMILES | Cc1ccc(NC2=N\C(=C/c3ccc4OCOc4c3)C(=O)N2)cc1C |t:6| |
Structure |
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