Reaction Details |
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Target | C-X-C chemokine receptor type 3 |
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Ligand | BDBM208728 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2216909 (CHEMBL5130041) |
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IC50 | 31±n/a nM |
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Citation | Caroff, E; Meyer, EA; Äänismaa, P; Froidevaux, S; Keller, M; Piali, L Design, Synthesis, and Pharmacological Evaluation of Benzimidazolo-thiazoles as Potent CXCR3 Antagonists with Therapeutic Potential in Autoimmune Diseases: Discovery of ACT-672125. J Med Chem65:11533-11549 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-X-C chemokine receptor type 3 |
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Name: | C-X-C chemokine receptor type 3 |
Synonyms: | AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40665.65 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 368 |
Sequence: | MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL
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BDBM208728 |
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n/a |
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Name | BDBM208728 |
Synonyms: | US9266876, 195 |
Type | Small organic molecule |
Emp. Form. | C21H20F3N7O2S |
Mol. Mass. | 491.489 |
SMILES | C[C@@H]1CN(CCN1C(=O)Cc1nnc(C)o1)c1sc(nc1-c1nc2ccccc2[nH]1)C(F)(F)F |
Structure |
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