| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Ligand | BDBM50595569 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2217028 (CHEMBL5130160) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Yin, L; Pan, Y; Xue, Y; Chen, X; You, T; Huang, J; Xu, Q; Hu, Q Design, Synthesis, and Biological Evaluations of Pyridyl 4,5,6,7-Tetrahydro-4,7-Methanobenzo[ J Med Chem65:11876-11888 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Synonyms: | CP17A_HUMAN | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450 C17 (CYP17 ) | Cytochrome P450 C17 (CYP17) | Cytochrome P450 CYP17 | Cytochrome P450-C17 | Cytochrome P450-C17 (CYP17) | P450-C17 | S17AH | Steroid 17-alpha-Monooxygenase (CYP17) | Steroid 17-alpha-hydroxylase/17,20 lyase | Steroid 17-alpha-monooxygenase | cytochrome P450 monooxygenase 17 alpha hydroxylase/17,20-lyase (CYP17) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 57382.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | E.coli expressing human CYP17 |
|---|
| Residue: | 508 |
|---|
| Sequence: | MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS
LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN
DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP
KVVFLIDSFKVKIKVRQAWREAQAEGST
|
|
|
|---|
| BDBM50595569 |
|---|
| n/a |
|---|
| Name | BDBM50595569 |
|---|
| Synonyms: | CHEMBL5184829 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H19N5O2 |
|---|
| Mol. Mass. | 373.4079 |
|---|
| SMILES | [H][C@@]12CC[C@@]([H])(C1)[C@]1(ON=C(c3cccnc3)[C@@]21[H])C(=O)Nc1ccc2[nH]ncc2c1 |r,t:10| |
|---|
| Structure | 
|
|---|
Search and Browse
