| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
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| Ligand | BDBM50595569 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2217049 (CHEMBL5130181) |
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| IC50 | 25±n/a nM |
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| Citation |  Yin, L; Pan, Y; Xue, Y; Chen, X; You, T; Huang, J; Xu, Q; Hu, Q Design, Synthesis, and Biological Evaluations of Pyridyl 4,5,6,7-Tetrahydro-4,7-Methanobenzo[ J Med Chem65:11876-11888 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B1, mitochondrial |
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| Name: | Cytochrome P450 11B1, mitochondrial |
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| Synonyms: | C11B1_RAT | Cyp11b-1 | Cyp11b1 | Cytochrome P450 11B | Cytochrome P450 11B1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57478.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1475489 |
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| Residue: | 499 |
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| Sequence: | MALRVTADVWLARPWQCLHRTRALGTTAKVAPKTLKPFEAIPQYSRNKWLKMIQILREQG
QENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPHRMPLEPWVAHR
ELRGLRRGVFLLNGADWRFNRLQLNPNMLSPKAIQSFVPFVDVVARDFVENLKKRMLENV
HGSMSINIQSNMFNYTMEASHFVISGERLGLTGHDLKPESVTFTHALHSMFKSTTQLMFL
PKSLTRWTSTRVWKEHFDSWDIISEYVTKCIKNVYRELAEGRQQSWSVISEMVAQSTLSM
DAIHANSMELIAGSVDTTAISLVMTLFELARNPDVQQALRQESLAAEASIVANPQKAMSD
LPLLRAALKETLRLYPVGSFVERIVHSDLVLQNYHVPAGTFVIIYLYSMGRNPAVFPRPE
RYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDMQMV
FRFLLMPSSSPFLTFRPVS
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| BDBM50595569 |
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| n/a |
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| Name | BDBM50595569 |
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| Synonyms: | CHEMBL5184829 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19N5O2 |
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| Mol. Mass. | 373.4079 |
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| SMILES | [H][C@@]12CC[C@@]([H])(C1)[C@]1(ON=C(c3cccnc3)[C@@]21[H])C(=O)Nc1ccc2[nH]ncc2c1 |r,t:10| |
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| Structure | 
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