| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50024372 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306119 (CHEMBL830069) |
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| IC50 | 540±n/a nM |
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| Citation |  Ujjainwalla, F; Warner, D; Snedden, C; Grisson, RD; Walsh, TF; Wyvratt, MJ; Kalyani, RN; Macneil, T; Tang, R; Weinberg, DH; Van der Ploeg, L; Goulet, MT Design and syntheses of melanocortin subtype-4 receptor agonists. Part 2: discovery of the dihydropyridazinone motif. Bioorg Med Chem Lett15:4023-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50024372 |
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| n/a |
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| Name | BDBM50024372 |
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| Synonyms: | CHEMBL2113043 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H36ClFN4O3S |
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| Mol. Mass. | 623.18 |
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| SMILES | COc1ccc(cc1)N1N=C(CC(CC[C@@H](C)NC(=O)[C@H]2CCNC[C@@H]2c2ccc(F)cc2)C1=O)Sc1ccc(Cl)cc1 |c:10| |
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| Structure | 
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