| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50171883 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303809 (CHEMBL829030) |
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| Ki | 49.5±n/a nM |
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| Citation |  Fiorino, F; Perissutti, E; Severino, B; Santagada, V; Cirillo, D; Terracciano, S; Massarelli, P; Bruni, G; Collavoli, E; Renner, C; Caliendo, G New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation. J Med Chem48:5495-503 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46445.29 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Binding assays were performed using rat hippocampal membranes. |
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| Residue: | 422 |
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| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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| BDBM50171883 |
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| n/a |
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| Name | BDBM50171883 |
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| Synonyms: | 4-[3-(4-Pyrimidin-2-yl-piperazin-1-yl)-propoxy]-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione | CHEMBL192828 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25N5O3 |
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| Mol. Mass. | 383.4442 |
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| SMILES | O=C1C2C3CC(C=C3)C2C(=O)N1OCCCN1CCN(CC1)c1ncccn1 |c:6| |
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| Structure | 
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