Reaction Details |
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Target | P2X purinoceptor 2 |
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Ligand | BDBM50596632 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2221594 (CHEMBL5134928) |
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IC50 | 890±n/a nM |
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Citation | Mahmood, A; Ali Shah, SJ; Iqbal, J Design and synthesis of adamantane-1-carbonyl thiourea derivatives as potent and selective inhibitors of h-P2X4 and h-P2X7 receptors: An Emerging therapeutic tool for treatment of inflammation and neurological disorders. Eur J Med Chem231:0 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 2 |
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Name: | P2X purinoceptor 2 |
Synonyms: | ATP receptor | P2RX2 | P2RX2_HUMAN | P2X2 | Purinergic receptor | PurinergicP2X2/3 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51765.18 |
Organism: | Homo sapiens (Human) |
Description: | PurinergicP2X2/3 0 HUMAN::Q9UBL9 |
Residue: | 471 |
Sequence: | MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYV
FIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQ
TQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVED
GASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFK
LGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYN
FRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCD
WILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSG
QEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
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BDBM50596632 |
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n/a |
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Name | BDBM50596632 |
Synonyms: | CHEMBL5187239 |
Type | Small organic molecule |
Emp. Form. | C29H20ClN7O10S3 |
Mol. Mass. | 758.158 |
SMILES | Nc1c2C(=O)c3ccccc3C(=O)c2c(Nc2ccc(Nc3nc(Cl)nc(Nc4cccc(c4)S(O)=O)n3)c(c2)S(O)(=O)=O)cc1S(O)(=O)=O |
Structure |
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