| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP3 |
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| Ligand | BDBM50594268 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2222292 (CHEMBL5135626) |
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| IC50 | 3100±n/a nM |
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| Citation |  Brusa, I; Sondo, E; Falchi, F; Pedemonte, N; Roberti, M; Cavalli, A Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives. J Med Chem65:5212-5243 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP3 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP3 |
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| Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT-3 | ADPRT3 | ADPRTL3 | ARTD3 | IRT1 | NAD(+) ADP-ribosyltransferase 3 | PARP-3 | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly[ADP-ribose] synthase 3 | hPARP-3 | pADPRT-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60091.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109545 |
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| Residue: | 533 |
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| Sequence: | MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
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| BDBM50594268 |
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| n/a |
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| Name | BDBM50594268 |
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| Synonyms: | CHEMBL5178746 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15NO2 |
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| Mol. Mass. | 253.2958 |
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| SMILES | O[C@@H]1[C@@H](CNC(=O)c2ccccc12)c1ccccc1 |r| |
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| Structure | 
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