| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50172802 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_322146 (CHEMBL883720) |
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| EC50 | 114±n/a nM |
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| Citation |  Caijo, F; Mosset, P; Grée, R; Audinot-Bouchez, V; Boutin, J; Renard, P; Caignard, DH; Dacquet, C Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs. Bioorg Med Chem Lett15:4421-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50172802 |
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| n/a |
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| Name | BDBM50172802 |
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| Synonyms: | CHEMBL383607 | Sodium 8-hydroxy-8-(2-pentyloxy-quinolin-3-yl)-oct-5-ynoate (9a) | Sodium; 8-hydroxy-8-(2-pentyloxy-quinolin-3-yl)-oct-5-ynoate |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26NO4 |
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| Mol. Mass. | 368.4467 |
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| SMILES | CCCCCOc1nc2ccccc2cc1C(O)CC#CCCCC([O-])=O |
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| Structure | 
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