Reaction Details |
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Target | B-cell lymphoma 6 protein |
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Ligand | BDBM50597114 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2222868 (CHEMBL5136202) |
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IC50 | 3100±n/a nM |
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Citation | Davis, OA; Cheung, KJ; Brennan, A; Lloyd, MG; Rodrigues, MJ; Pierrat, OA; Collie, GW; Le Bihan, YV; Huckvale, R; Harnden, AC; Varela, A; Bright, MD; Eve, P; Hayes, A; Henley, AT; Carter, MD; McAndrew, PC; Talbot, R; Burke, R; van Montfort, RLM; Raynaud, FI; Rossanese, OW; Meniconi, M; Bellenie, BR; Hoelder, S Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors. J Med Chem65:8169-8190 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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B-cell lymphoma 6 protein |
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Name: | B-cell lymphoma 6 protein |
Synonyms: | B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51 |
Type: | PROTEIN |
Mol. Mass.: | 78866.89 |
Organism: | Homo sapiens |
Description: | ChEMBL_117695 |
Residue: | 706 |
Sequence: | MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSI
FTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDT
CRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAF
APSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPG
EYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKAS
KEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASG
SPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEP
ENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGS
QSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQT
HSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEK
PYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHC
EKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
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BDBM50597114 |
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n/a |
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Name | BDBM50597114 |
Synonyms: | CHEMBL5185841 |
Type | Small organic molecule |
Emp. Form. | C22H22ClN5O2 |
Mol. Mass. | 423.895 |
SMILES | CC(C)C1CCOc2c(N1)c1cc(Nc3ccnc(Cl)c3C#N)ccc1n(C)c2=O |
Structure |
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