| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cGMP-dependent protein kinase 1 |
|---|
| Ligand | BDBM50597473 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2223527 (CHEMBL5136861) |
|---|
| IC50 | 39±n/a nM |
|---|
| Citation |  Ladduwahetty, T; Lee, MR; Maillard, MC; Cachope, R; Todd, D; Barnes, M; Beaumont, V; Chauhan, A; Gallati, C; Haughan, AF; Kempf, G; Luckhurst, CA; Matthews, K; McAllister, G; Mitchell, P; Patel, H; Rose, M; Saville-Stones, E; Steinbacher, S; Stott, AJ; Thatcher, E; Tierney, J; Urbonas, L; Munoz-Sanjuan, I; Dominguez, C Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease. J Med Chem65:9819-9845 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cGMP-dependent protein kinase 1 |
|---|
| Name: | cGMP-dependent protein kinase 1 |
|---|
| Synonyms: | GMP-dependent protein kinase I | KGP1_HUMAN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | Protein Kinase G | cGMP-dependent protein kinase | cGMP-dependent protein kinase 1 | cGMP-dependent protein kinase 1 beta |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 76358.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13976 |
|---|
| Residue: | 671 |
|---|
| Sequence: | MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTR
AQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMY
PVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTAT
VKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEET
HYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDV
RTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDF
NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF
IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI
IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD
YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS
ERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPP
PDDNSGWDIDF
|
|
|
|---|
| BDBM50597473 |
|---|
| n/a |
|---|
| Name | BDBM50597473 |
|---|
| Synonyms: | CHEMBL5181094 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19N3O2 |
|---|
| Mol. Mass. | 333.3838 |
|---|
| SMILES | COc1cccc(c1)[C@@H](C)NC(=O)c1ccc(nc1)-c1ccncc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
