| Reaction Details |
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 | Report a problem with these data |
| Target | Malonyl-CoA decarboxylase, mitochondrial |
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| Ligand | BDBM50176177 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_330757 (CHEMBL861921) |
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| IC50 | 37000±n/a nM |
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| Citation |  Cheng, JF; Chen, M; Liu, B; Hou, Z; Arrhenius, T; Nadzan, AM Design and synthesis of heterocyclic malonyl-CoA decarboxylase inhibitors. Bioorg Med Chem Lett16:695-700 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Malonyl-CoA decarboxylase, mitochondrial |
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| Name: | Malonyl-CoA decarboxylase, mitochondrial |
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| Synonyms: | DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55018.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_665404 |
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| Residue: | 493 |
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| Sequence: | MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKT
PAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAA
VLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNG
VLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFF
SHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQG
VELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSEC
KEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVA
NFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQV
LSLVAQFQKNSKL
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| BDBM50176177 |
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| n/a |
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| Name | BDBM50176177 |
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| Synonyms: | CHEMBL377710 | ethyl 3-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-isopropyl-1H-imidazol-5-yl)-2-methylpropanoate |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24F6N2O3 |
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| Mol. Mass. | 466.4173 |
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| SMILES | CCOC(=O)C(C)Cc1cnc(C(C)C)n1-c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F |
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| Structure | 
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