Ki Summary

Reaction Details

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Target

Motilin receptor

Ligand

BDBM50599727

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2231450 (CHEMBL5145222)

EC50

46±n/a nM

Citation

Toda, N; Shida, T; Takano, R; Katagiri, T; Hirouchi, M; Abe, M; Soma, K; Nakagami, Y; Yamazaki, M Discovery of DS-3801b, a non-macrolide GPR38 agonist with N-methylanilide structure. Bioorg Med Chem Lett59:0 (2022) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Motilin receptor

Name:

Motilin receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

45365.95

Organism:

Homo sapiens (Human)

Description:

ChEMBL_122664

Residue:

412

Sequence:

MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTV
MLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEG
CTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVE
QDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPA
QLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVL
LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISK
KYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG

BDBM50599727

n/a

Name

BDBM50599727

Synonyms:

CHEMBL5179463

Type

Small organic molecule

Emp. Form.

C26H34FN3O2

Mol. Mass.

439.5655

SMILES

CN(C(=O)[C@H]1CC[C@@H](CC1)Oc1ccc(F)cc1)c1ccc(CN2CCNCC2)c(C)c1 |r,wU:4.3,wD:7.10,(-0,-5.77,;-0,-4.23,;1.33,-3.46,;2.67,-4.23,;1.33,-1.92,;-0,-1.15,;-0,.39,;1.33,1.16,;2.67,.39,;2.67,-1.15,;1.33,2.7,;2.67,3.47,;2.67,5.01,;4,5.77,;5.33,5,;6.66,5.77,;5.33,3.47,;4.01,2.69,;-1.33,-3.46,;-1.33,-1.92,;-2.66,-1.15,;-4,-1.92,;-5.33,-1.15,;-5.33,.39,;-6.66,1.16,;-6.66,2.7,;-5.33,3.47,;-4,2.7,;-4,1.16,;-4,-3.47,;-5.33,-4.24,;-2.66,-4.23,)|

Structure