| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50177312 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_334534 (CHEMBL862517) |
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| Ki | >4949±n/a nM |
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| Citation |  Cherney, RJ; King, BW; Gilmore, JL; Liu, RQ; Covington, MB; Duan, JJ; Decicco, CP Conversion of potent MMP inhibitors into selective TACE inhibitors. Bioorg Med Chem Lett16:1028-31 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50177312 |
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| n/a |
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| Name | BDBM50177312 |
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| Synonyms: | 2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzyl]-1,1-dioxo-isothiazolidine-3-carboxylic acid hydroxyamide | CHEMBL204495 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N3O5S |
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| Mol. Mass. | 441.5 |
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| SMILES | Cc1cc(COc2ccc(CN3C(CCS3(=O)=O)C(=O)NO)cc2)c2ccccc2n1 |
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| Structure | 
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