| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-2 |
|---|
| Ligand | BDBM50177986 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_326725 (CHEMBL859745) |
|---|
| IC50 | 39400±n/a nM |
|---|
| Citation |  Mai, A; Massa, S; Lavu, S; Pezzi, R; Simeoni, S; Ragno, R; Mariotti, FR; Chiani, F; Camilloni, G; Sinclair, DA Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem48:7789-95 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NAD-dependent protein deacetylase sirtuin-2 |
|---|
| Name: | NAD-dependent protein deacetylase sirtuin-2 |
|---|
| Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
|---|
| Type: | Hydrolase |
|---|
| Mol. Mass.: | 43172.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 389 |
|---|
| Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
|
|
|
|---|
| BDBM50177986 |
|---|
| n/a |
|---|
| Name | BDBM50177986 |
|---|
| Synonyms: | (S)-sirtinol | CHEMBL197282 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H22N2O2 |
|---|
| Mol. Mass. | 394.4651 |
|---|
| SMILES | C[C@H](NC(=O)c1ccccc1\N=C\c1c(O)ccc2ccccc12)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
