| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fyn |
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| Ligand | BDBM50602863 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2242299 (CHEMBL5156509) |
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| IC50 | 91±n/a nM |
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| Citation |  Demuro, S; Sauvey, C; Tripathi, SK; Di Martino, RMC; Shi, D; Ortega, JA; Russo, D; Balboni, B; Giabbai, B; Storici, P; Girotto, S; Abagyan, R; Cavalli, A ARN25068, a versatile starting point towards triple GSK-3?/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem229:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Fyn |
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| Name: | Tyrosine-protein kinase Fyn |
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| Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
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| Type: | Enzyme |
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| Mol. Mass.: | 60762.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06241 |
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| Residue: | 537 |
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| Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
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| BDBM50602863 |
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| n/a |
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| Name | BDBM50602863 |
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| Synonyms: | CHEMBL1997924 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18N6S |
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| Mol. Mass. | 362.451 |
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| SMILES | C(Nc1nc(Nc2cc([nH]n2)C2CC2)c2sccc2n1)c1ccccc1 |
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| Structure | 
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