Ki Summary

Reaction Details

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Target

B-cell CLL/lymphoma 9 protein

Ligand

BDBM50409773

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2268492

IC50

6200±n/a nM

Citation

Li, Z; Zhang, M; Teuscher, KB; Ji, H Discovery of 1-Benzoyl 4-Phenoxypiperidines as Small-Molecule Inhibitors of the ?-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction. J Med Chem64:11195-11218 (2021) [PubMed]

More Info.:

Get all data from this article, Assay Method

B-cell CLL/lymphoma 9 protein

Name:

B-cell CLL/lymphoma 9 protein

Synonyms:

Type:

PROTEIN

Mol. Mass.:

149313.19

Organism:

Homo sapiens

Description:

ChEMBL_117069

Residue:

1426

Sequence:

MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQ
PSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDS
DIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVF
STEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPA
PANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPP
DGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRE
RSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGP
GPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFY
EEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINM
PHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIP
DGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNR
MIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDV
NLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMG
PRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRG
LGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPA
AAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPA
MLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPS
STPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPM
GMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQG
FPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGG
PDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGR
KQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPA
FLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGM
MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF

BDBM50409773

n/a

Name

BDBM50409773

Synonyms:

CHEMBL5277893

Type

Small organic molecule

Emp. Form.

C36H53Cl2FN4O3

Mol. Mass.

679.735

SMILES

Cl.Cl.CC(C)(C)C1CCC(CC1)c1cc(ccc1O[C@H]1CCNC1)C(=O)N1CCC(CC1)Oc1cc(ccc1F)N1CCNCC1 |r,wD:19.18,(-11.29,-4.66,;10.95,-4.5,;11.98,3.1,;10.65,3.87,;11.98,4.64,;10.65,5.41,;9.31,3.1,;9.31,1.56,;7.98,.8,;6.64,1.56,;6.64,3.1,;7.98,3.87,;5.31,.8,;3.98,1.56,;2.64,.8,;2.64,-.74,;3.98,-1.51,;5.31,-.74,;6.64,-1.51,;6.64,-3.05,;5.41,-3.98,;5.87,-5.41,;7.41,-5.41,;7.93,-3.98,;1.31,1.56,;1.31,3.1,;-.03,.8,;-1.36,1.56,;-2.69,.8,;-2.69,-.74,;-1.36,-1.51,;-.03,-.74,;-4.03,-1.51,;-5.36,-.74,;-6.64,-1.51,;-7.98,-.74,;-7.98,.8,;-6.64,1.56,;-5.36,.8,;-4.03,1.56,;-9.31,-1.51,;-10.65,-.74,;-11.98,-1.51,;-11.98,-3.05,;-10.65,-3.82,;-9.31,-3.05,)|

Structure