Ki Summary

Reaction Details

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Target

B-cell CLL/lymphoma 9 protein

Ligand

BDBM50409774

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2268492

IC50

6700±n/a nM

Citation

Li, Z; Zhang, M; Teuscher, KB; Ji, H Discovery of 1-Benzoyl 4-Phenoxypiperidines as Small-Molecule Inhibitors of the ?-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction. J Med Chem64:11195-11218 (2021) [PubMed]

More Info.:

Get all data from this article, Assay Method

B-cell CLL/lymphoma 9 protein

Name:

B-cell CLL/lymphoma 9 protein

Synonyms:

Type:

PROTEIN

Mol. Mass.:

149313.19

Organism:

Homo sapiens

Description:

ChEMBL_117069

Residue:

1426

Sequence:

MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQ
PSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDS
DIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVF
STEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPA
PANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPP
DGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRE
RSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGP
GPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFY
EEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINM
PHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIP
DGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNR
MIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDV
NLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMG
PRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRG
LGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPA
AAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPA
MLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPS
STPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPM
GMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQG
FPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGG
PDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGR
KQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPA
FLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGM
MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF

BDBM50409774

n/a

Name

BDBM50409774

Synonyms:

CHEMBL5268580

Type

Small organic molecule

Emp. Form.

C36H53Cl2FN4O3

Mol. Mass.

679.735

SMILES

Cl.Cl.CC(C)(C)C1CCC(CC1)c1cc(ccc1O[C@H]1CCNC1)C(=O)N1CCC(CC1)Oc1ccc(F)c(c1)N1CCNCC1 |r,wD:19.18,(-10.54,-4.96,;9.66,-5.16,;12.01,3.1,;10.67,3.87,;12.01,4.64,;10.67,5.41,;9.34,3.1,;9.34,1.56,;8,.8,;6.67,1.56,;6.67,3.1,;8,3.87,;5.34,.8,;4,1.56,;2.67,.8,;2.67,-.74,;4,-1.51,;5.34,-.74,;6.67,-1.51,;6.67,-3.05,;5.44,-3.98,;5.9,-5.41,;7.44,-5.41,;7.9,-3.98,;1.33,1.56,;1.33,3.1,;,.8,;-1.33,1.56,;-2.67,.8,;-2.67,-.74,;-1.33,-1.51,;,-.74,;-4,-1.51,;-5.34,-.74,;-5.34,.8,;-6.67,1.56,;-8,.8,;-9.34,1.56,;-8,-.74,;-6.67,-1.51,;-9.34,-1.51,;-10.67,-.74,;-12.01,-1.51,;-12.01,-3.05,;-10.67,-3.82,;-9.34,-3.05,)|

Structure