| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-ketoglutarate-dependent dioxygenase FTO |
|---|
| Ligand | BDBM50596053 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2269248 |
|---|
| IC50 | 810±n/a nM |
|---|
| Citation |  Perry, GS; Das, M; Woon, ECY Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets. J Med Chem64:16974-17003 (2021) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-ketoglutarate-dependent dioxygenase FTO |
|---|
| Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
|---|
| Synonyms: | FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58263.75 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1515854 |
|---|
| Residue: | 505 |
|---|
| Sequence: | MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
|
|
|
|---|
| BDBM50596053 |
|---|
| n/a |
|---|
| Name | BDBM50596053 |
|---|
| Synonyms: | CHEMBL5173876 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H15N3O4 |
|---|
| Mol. Mass. | 325.3187 |
|---|
| SMILES | OC(=O)\C=C\C(=O)NNC(=O)c1cnccc1Cc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
