| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Ligand | BDBM50195495 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_425008 (CHEMBL911428) |
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| IC50 | >10000±n/a nM |
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| Citation |  Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome. Bioorg Med Chem Lett16:6241-5 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Synonyms: | 11-beta-hydroxysteroid dehydrogenase 2 | DHI2_RAT | Hsd11b2 | Hsd11k |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43740.05 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_735659 |
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| Residue: | 400 |
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| Sequence: | MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVV
LAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNGPG
ALELRARCSPRLKLLQMDLTKPEDISRVLEITKAHTASTGLWGLVNNAGLNMVVADVELS
PVVTFRECMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIA
LLMDTFSCELLPWGIKVSIIQPGCFKTEAVTNVNLWEKRKQLLLANLPRELLQAYGEDYI
EHLHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYTGRGLGLMYFIHHYLPGGLRR
RFLQNFFISHLLPRALRPGQPGPVHDTTQDPNPSPTVSAL
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| BDBM50195495 |
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| n/a |
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| Name | BDBM50195495 |
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| Synonyms: | 3-((2R,6R)-1-(4-amino-3,5-dichlorobenzoyl)-2,6-dimethylpiperidin-4-yl)benzo[d]oxazol-2(3H)-one | CHEMBL435136 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21Cl2N3O3 |
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| Mol. Mass. | 434.316 |
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| SMILES | C[C@@H]1CC(C[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1)n1c2ccccc2oc1=O |
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| Structure | 
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