| Reaction Details |
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 | Report a problem with these data |
| Target | Lethal factor |
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| Ligand | BDBM50485657 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2283290 |
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| IC50 | 3000±n/a nM |
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| Citation |  Arshad, JZ; Hanif, M Hydroxypyrone derivatives in drug discovery: from chelation therapy to rational design of metalloenzyme inhibitors. RSC Med Chem13:1127-1149 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Lethal factor |
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| Name: | Lethal factor |
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| Synonyms: | Anthrax Lethal Factor (LF) | Anthrax lethal factor | Antrax lethal toxin | LEF_BACAN | lef | lethal factor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93758.56 |
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| Organism: | Bacillus anthracis |
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| Description: | ChEMBL_1460338 |
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| Residue: | 809 |
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| Sequence: | MNIKKEFIKVISMSCLVTAITLSGPVFIPLVQGAGGHGDVGMHVKEKEKNKDENKRKDEE
RNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIGGKIYIVDGD
ITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPVLVIQSSEDYVENTEKALNV
YYEIGKILSRDILSKINQPYQKFLDVLNTIKNASDSDGQDLLFTNQLKEHPTDFSVEFLE
QNSNEVQEVFAKAFAYYIEPQHRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLAR
YEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSS
DFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYD
INQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLT
ATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSP
DTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNIN
QEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNG
RFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHE
FGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHST
DHAERLKVQKNAPKTFQFINDQIKFIINS
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| BDBM50485657 |
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| n/a |
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| Name | BDBM50485657 |
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| Synonyms: | CHEMBL2146996 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17NOS |
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| Mol. Mass. | 307.409 |
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| SMILES | Cc1c(O)c(=S)ccn1Cc1ccc(cc1)-c1ccccc1 |
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| Structure | 
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