| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Ligand | BDBM385170 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2290899 |
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| IC50 | 37±n/a nM |
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| Citation |  Lindberg, MF; Deau, E; Arfwedson, J; George, N; George, P; Alfonso, P; Corrionero, A; Meijer, L Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases. J Med Chem66:4106-4130 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Synonyms: | DYRK2 | DYRK2_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66690.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1508025 |
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| Residue: | 601 |
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| Sequence: | MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNA
AAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLP
VVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE
IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAY
DHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMT
FELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG
RSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYP
LLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGG
RSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP
KPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLV
S
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| BDBM385170 |
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| n/a |
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| Name | BDBM385170 |
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| Synonyms: | US10287267, Compound 330 | US10508099, Compound 330 | US10556885, Compound 330 | US11174244, Compound 330 | US11673881, Compound 330 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N5O3S |
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| Mol. Mass. | 413.493 |
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| SMILES | Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CC3)S(C)(=O)=O)cc2c1 |
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| Structure | 
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