| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-2 |
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| Ligand | BDBM50613308 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2291820 |
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| IC50 | 461±n/a nM |
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| Citation |  Amrhein, JA; Wang, G; Berger, BT; Berger, LM; Kalampaliki, AD; Krämer, A; Knapp, S; Hanke, T Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2. ACS Med Chem Lett14:833-840 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein receptor type-2 |
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| Name: | Bone morphogenetic protein receptor type-2 |
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| Synonyms: | BMPR2 | BMPR2_HUMAN | Bone Morphogenetic Protein Receptor type II (BMPR2) | Bone morphogenetic protein receptor type-2 | PPH1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 115194.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774306 |
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| Residue: | 1038 |
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| Sequence: | MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILC
SKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCST
DLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRK
QGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNF
INEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVS
SCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTG
NRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRC
TDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETI
EDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKI
GPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPS
PETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTE
EDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQ
QDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSN
LKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVT
HRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRT
NSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGEST
QDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLA
EGGTATTMVSKDIGMNCL
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| BDBM50613308 |
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| n/a |
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| Name | BDBM50613308 |
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| Synonyms: | CHEMBL5271220 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15N7O |
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| Mol. Mass. | 321.3366 |
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| SMILES | O=C1NCCc2cccc(Nc3nccc(Nc4cc1[nH]n4)n3)c2 |
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| Structure | 
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