| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Macrophage colony-stimulating factor 1 receptor |
|---|
| Ligand | BDBM50613394 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2292225 |
|---|
| IC50 | >2000±n/a nM |
|---|
| Citation |  Luo, G; Chen, L; Burton, CR; Xiao, H; Sivaprakasam, P; Krause, CM; Cao, Y; Liu, N; Lippy, J; Clarke, WJ; Snow, K; Raybon, J; Arora, V; Pokross, M; Kish, K; Lewis, HA; Langley, DR; Macor, JE; Dubowchik, GM Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors. J Med Chem59:1041-51 (2016) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Macrophage colony-stimulating factor 1 receptor |
|---|
| Name: | Macrophage colony-stimulating factor 1 receptor |
|---|
| Synonyms: | CSF1R | CSF1R_HUMAN | FMS | Fms proto-oncogene | Macrophage colony stimulating factor receptor | Macrophage colony-stimulating factor 1 receptor (FMS) | Macrophage colony-stimulating factor 1 receptor (c-FMS) | Macrophage colony-stimulating factor 1 receptor (cFMS) | Proto-oncogene c-Fms | Tyrosine Kinase CSF1-R | c-fms | cFMS |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 107979.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07333 |
|---|
| Residue: | 972 |
|---|
| Sequence: | MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTL
YSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFED
QDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL
MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN
NTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAY
LNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY
RHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCA
ASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN
QTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKY
KQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT
AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVL
VITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGV
DTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA
ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS
YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR
PTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIA
QPLLQPNNYQFC
|
|
|
|---|
| BDBM50613394 |
|---|
| n/a |
|---|
| Name | BDBM50613394 |
|---|
| Synonyms: | CHEMBL5278465 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H17ClN4O2 |
|---|
| Mol. Mass. | 392.838 |
|---|
| SMILES | Clc1ccc(cc1)-c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
