Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | MAP/microtubule affinity-regulating kinase 3 |
---|
Ligand | BDBM50613394 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2292285 |
---|
IC50 | >50000±n/a nM |
---|
Citation | Luo, G; Chen, L; Burton, CR; Xiao, H; Sivaprakasam, P; Krause, CM; Cao, Y; Liu, N; Lippy, J; Clarke, WJ; Snow, K; Raybon, J; Arora, V; Pokross, M; Kish, K; Lewis, HA; Langley, DR; Macor, JE; Dubowchik, GM Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors. J Med Chem59:1041-51 (2016) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
MAP/microtubule affinity-regulating kinase 3 |
---|
Name: | MAP/microtubule affinity-regulating kinase 3 |
Synonyms: | 2.7.11.1 | C-TAK1 | CTAK1 | Cdc25C-associated protein kinase 1 | ELKL motif kinase 2 | EMK-2 | EMK2 | MAP/microtubule affinity-regulating kinase 3 | MAP/microtubule affinity-regulating kinase 3 (MARK 3) | MARK3 | MARK3_HUMAN | Par-1a | Protein kinase STK10 | Ser/Thr protein kinase PAR-1 | Serine/threonine-protein kinase c-TAK1 | Serine/threonine-protein kinase p78 |
Type: | Protein |
Mol. Mass.: | 84525.94 |
Organism: | Homo sapiens (Human) |
Description: | P27448 |
Residue: | 753 |
Sequence: | MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ
IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT
YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSD
HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK
ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS
THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG
STNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRF
TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL
PRLSLNGVRFKRISGTSIAFKNIASKIANELKL
|
|
|
BDBM50613394 |
---|
n/a |
---|
Name | BDBM50613394 |
Synonyms: | CHEMBL5278465 |
Type | Small organic molecule |
Emp. Form. | C21H17ClN4O2 |
Mol. Mass. | 392.838 |
SMILES | Clc1ccc(cc1)-c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 |
Structure |
|