| Reaction Details |
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 | Report a problem with these data |
| Target | Homeodomain-interacting protein kinase 1 |
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| Ligand | BDBM50614163 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2295973 |
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| IC50 | 1800000±n/a nM |
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| Citation |  Davis-Gilbert, ZW; Krämer, A; Dunford, JE; Howell, S; Senbabaoglu, F; Wells, CI; Bashore, FM; Havener, TM; Smith, JL; Hossain, MA; Oppermann, U; Drewry, DH; Axtman, AD Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2. ACS Med Chem Lett14:432-441 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Homeodomain-interacting protein kinase 1 |
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| Name: | Homeodomain-interacting protein kinase 1 |
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| Synonyms: | HIPK1 | HIPK1_HUMAN | Homeodomain-interacting protein kinase 1 (HIPK1) | KIAA0630 | MYAK | NBAK2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 130868.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1459267 |
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| Residue: | 1210 |
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| Sequence: | MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSH
QVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQK
CGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQH
EILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSR
LSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVA
TALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRA
PEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGT
KTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTD
MLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNME
ICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATL
SLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQ
TGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATIT
PQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMI
PEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSS
LPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPS
PPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSA
LRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQ
SSGCCITPTGYRAQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAPLSQA
PYTFQHGSPLHSTGHPHLAPAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSR
HAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLS
PTKISQYSYL
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| BDBM50614163 |
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| n/a |
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| Name | BDBM50614163 |
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| Synonyms: | CHEMBL5288779 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14N4O2 |
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| Mol. Mass. | 330.3401 |
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| SMILES | OC(=O)c1ccc2c(c1)nc(NCc1ccccc1)c1ncncc21 |
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| Structure | 
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