| Reaction Details |
|---|
 | Report a problem with these data |
| Target | ATPase family AAA domain-containing protein 2 |
|---|
| Ligand | BDBM50615276 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2301492 |
|---|
| Kd | >10000±n/a nM |
|---|
| Citation |  Crawford, TD; Vartanian, S; Côté, A; Bellon, S; Duplessis, M; Flynn, EM; Hewitt, M; Huang, HR; Kiefer, JR; Murray, J; Nasveschuk, CG; Pardo, E; Romero, FA; Sandy, P; Tang, Y; Taylor, AM; Tsui, V; Wang, J; Wang, S; Zawadzke, L; Albrecht, BK; Magnuson, SR; Cochran, AG; Stokoe, D Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorg Med Chem Lett27:3534-3541 (2017) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| ATPase family AAA domain-containing protein 2 |
|---|
| Name: | ATPase family AAA domain-containing protein 2 |
|---|
| Synonyms: | AAA nuclear coregulator cancer-associated protein | ANCCA | ATAD2 | ATAD2_HUMAN | PRO2000 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 158546.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1500426 |
|---|
| Residue: | 1390 |
|---|
| Sequence: | MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGS
SVKEVETYHRTRALRSLRKDAQNSSDSSFEKNVEITEQLANGRHFTRQLARQQADKKKEE
HREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKLITNT
AEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEG
SVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRK
ATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDS
TSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLD
SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL
ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR
SSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPD
KEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYT
TSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEAL
QRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHL
NRNACYQPMSFRPRILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEE
TCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPH
SALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLP
VAPPPEPRSLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPD
YVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACA
LRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSD
PEQNEKLKTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIES
DTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSRKTTA
CTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILS
QPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLYAVISQCIYRHRKDHDKTSLIQKME
QEVENFSCSR
|
|
|
|---|
| BDBM50615276 |
|---|
| n/a |
|---|
| Name | BDBM50615276 |
|---|
| Synonyms: | CHEMBL5270178 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23N3O3 |
|---|
| Mol. Mass. | 377.4363 |
|---|
| SMILES | C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N2CCOCC2)c2cc[nH]c2c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
