| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-7 |
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| Ligand | BDBM50216414 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_440104 (CHEMBL890416) |
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| IC50 | 34.8±n/a nM |
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| Citation |  Chu, W; Rothfuss, J; d'Avignon, A; Zeng, C; Zhou, D; Hotchkiss, RS; Mach, RH Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. J Med Chem50:3751-5 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-7 |
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| Name: | Caspase-7 |
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| Synonyms: | Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase |
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| Type: | Enzyme |
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| Mol. Mass.: | 34273.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55210 |
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| Residue: | 303 |
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| Sequence: | MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
FSQ
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| BDBM50216414 |
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| n/a |
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| Name | BDBM50216414 |
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| Synonyms: | 1-(4-bromo-benzyl)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione | CHEMBL376112 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23BrN2O5S |
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| Mol. Mass. | 555.44 |
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| SMILES | Brc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CCC[C@H]2COc2ccccc2)cc1 |
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| Structure | 
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