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TargetGlutamate receptor ionotropic, NMDA 2B
LigandBDBM50242448
Substrate/Competitorn/a
Meas. Tech.ChEMBL_533731 (CHEMBL974284)
IC50 500±n/a nM
Citation Teichert, RW; Jimenez, EC; Twede, V; Watkins, M; Hollmann, M; Bulaj, G; Olivera, BM Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. J Biol Chem282:36905-13 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glutamate receptor ionotropic, NMDA 2B
Name:Glutamate receptor ionotropic, NMDA 2B
Synonyms:GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Grin2b | N-methyl D-aspartate receptor subtype 2B | NMDA receptor subunit N2B (GluN2B) | NMDAR2B | NMDE2_RAT | NR2B
Type:Protein
Mol. Mass.:166077.66
Organism:Rattus norvegicus (Rat)
Description:Q00960
Residue:1482
Sequence:
MKPSAECCSPKFWLVLAVLAVSGSKARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH
HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL
TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ
DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIAII
TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP
KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
SVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL
VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR
SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF
TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV
DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS
LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI
LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR
LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS
DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSTSSIDGLYDCDNPPFTTQPRSISK
KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR
RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK
ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHLKHGTGEKHGVVGGVPAPWEKN
LTNVDWEDRSGGNFCRSCPSKLHNYSSTVAGQNSGRQACIRCEACKKAGNLYDISEDNSL
QELDQPAAPVAVTSNASSTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
SVSLKDKGRFMDGSPYAHMFEMPAGESSFANKSSVPTAGHHHNNPGSGYMLSKSLYPDRV
TQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKTRPDFRALVTNKPVVVTLHGAVPGRF
QKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50242448
n/a
NameBDBM50242448
Synonyms:CHEMBL526324
TypeSmall organic molecule
Emp. Form.C91H141N27O36
Mol. Mass.2189.2525
SMILESCC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](CCC(O)=O)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(N)=O |r,wU:81.89,73.74,57.59,43.50,24.24,98.100,121.123,135.138,146.148,wD:61.71,52.54,29.41,12.20,4.4,109.111,130.133,140.142,75.77,(1.79,-21.01,;1.79,-19.47,;3.13,-18.7,;.46,-18.7,;.46,-17.15,;-.87,-16.38,;-2.2,-17.15,;-2.2,-18.69,;-3.53,-16.38,;-4.86,-17.15,;-6.2,-16.38,;-6.2,-14.84,;-7.52,-17.15,;-7.53,-18.69,;-6.74,-20.01,;-7.49,-21.35,;-9.03,-21.37,;-6.7,-22.67,;-5.2,-19.98,;-4.41,-21.3,;-4.45,-18.63,;-8.86,-16.37,;-10.19,-17.14,;-10.19,-18.68,;-11.52,-16.37,;-11.52,-14.84,;-12.87,-17.14,;-14.2,-16.37,;-14.2,-14.83,;-15.54,-17.14,;-15.54,-18.68,;-14.19,-19.45,;-12.96,-18.55,;-11.71,-19.45,;-12.18,-20.9,;-11.42,-22.23,;-12.18,-23.56,;-13.73,-23.57,;-14.49,-22.23,;-13.73,-20.9,;-16.87,-16.37,;-18.19,-17.13,;-18.19,-18.68,;-19.54,-16.36,;-19.54,-14.83,;-18.19,-14.06,;-18.19,-12.52,;-16.86,-11.75,;-16.86,-10.22,;-20.86,-17.13,;-22.19,-16.36,;-22.19,-14.82,;-23.53,-17.12,;-23.53,-18.67,;-24.86,-16.35,;-26.19,-17.12,;-26.19,-18.66,;-27.53,-16.35,;-28.86,-17.12,;-30.19,-16.35,;-30.19,-14.81,;-31.53,-17.12,;-31.53,-18.66,;-30.72,-19.97,;-31.46,-21.32,;-33.01,-21.37,;-30.66,-22.64,;-29.18,-19.93,;-28.38,-21.25,;-28.45,-18.58,;-32.86,-16.35,;-34.18,-17.11,;-34.18,-18.65,;-35.51,-16.34,;-35.43,-14.8,;-37.09,-14.46,;-37.78,-12.94,;-37.91,-15.92,;-36.77,-17.17,;-36.82,-18.69,;-35.52,-19.52,;-38.17,-19.43,;-39.49,-18.63,;-40.84,-19.37,;-42.16,-18.57,;-42.11,-17.03,;-43.5,-19.3,;-38.21,-20.97,;-36.91,-21.78,;-35.55,-21.04,;-36.95,-23.31,;-35.63,-24.11,;-27.53,-14.81,;-26.19,-14.05,;-28.86,-14.04,;1.79,-16.39,;1.79,-14.86,;3.13,-17.16,;4.45,-16.39,;4.45,-14.86,;5.79,-14.09,;5.79,-12.55,;7.13,-11.78,;7.13,-10.24,;5.8,-9.48,;8.46,-9.47,;5.79,-17.17,;5.79,-18.7,;7.13,-16.4,;8.45,-17.16,;8.45,-18.71,;9.2,-20.05,;8.41,-21.38,;6.87,-21.35,;9.16,-22.71,;10.75,-20.07,;11.5,-21.42,;11.54,-18.75,;9.79,-16.4,;9.79,-14.86,;11.13,-17.17,;12.45,-16.4,;12.45,-14.87,;13.79,-14.1,;13.79,-12.56,;15.13,-11.79,;15.13,-10.25,;13.79,-17.17,;13.79,-18.71,;15.12,-16.41,;16.45,-17.17,;16.45,-18.72,;17.78,-16.4,;17.78,-14.87,;19.12,-17.18,;20.45,-16.41,;20.45,-14.88,;21.78,-17.18,;21.78,-18.73,;23.11,-16.42,;24.45,-17.19,;24.45,-18.73,;25.78,-19.5,;25.78,-16.42,;25.78,-14.88,;27.11,-17.19,;28.44,-16.42,;28.44,-14.89,;29.78,-14.11,;31.11,-14.89,;29.78,-12.58,;29.78,-17.19,;31.1,-16.42,;29.78,-18.73,)|
Structure
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