Reaction Details |
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Target | Plasminogen activator inhibitor 1 |
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Ligand | BDBM50111274 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_531176 (CHEMBL974062) |
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IC50 | 5000±n/a nM |
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Citation | Schobert, R; Schlenk, A Tetramic and tetronic acids: an update on new derivatives and biological aspects. Bioorg Med Chem16:4203-21 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Plasminogen activator inhibitor 1 |
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Name: | Plasminogen activator inhibitor 1 |
Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1 |
Type: | Enzyme |
Mol. Mass.: | 45064.00 |
Organism: | Homo sapiens (Human) |
Description: | P05121 |
Residue: | 402 |
Sequence: | MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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BDBM50111274 |
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n/a |
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Name | BDBM50111274 |
Synonyms: | 8-(4-(1-(4-chlorophenyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxamido)phenoxy)octanoic acid | 8-(4-{[1-(4-Chloro-phenyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonyl]-amino}-phenoxy)-octanoic acid | CHEMBL10213 |
Type | Small organic molecule |
Emp. Form. | C25H27ClN2O6 |
Mol. Mass. | 486.945 |
SMILES | OC(=O)CCCCCCCOc1ccc(NC(=O)C2C(=O)CN(C2=O)c2ccc(Cl)cc2)cc1 |
Structure |
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