Reaction Details |
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Target | Matrix metalloproteinase-9 |
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Ligand | BDBM50246792 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_557954 (CHEMBL963052) |
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IC50 | 3.0±n/a nM |
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Citation | Ledour, G; Moroy, G; Rouffet, M; Bourguet, E; Guillaume, D; Decarme, M; Elmourabit, H; Augé, F; Alix, AJ; Laronze, JY; Bellon, G; Hornebeck, W; Sapi, J Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity. Bioorg Med Chem16:8745-59 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Matrix metalloproteinase-9 |
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Name: | Matrix metalloproteinase-9 |
Synonyms: | 67 kDa matrix metalloproteinase-9 | 82 kDa matrix metalloproteinase-9 | 92 kDa gelatinase | 92 kDa type IV collagenase | CLG4B | GELB | Gelatinase B | MMP-9 | MMP9 | MMP9_HUMAN | Matrix metalloproteinase 9 (MMP-9) | Matrix metalloproteinase-9 (MMP-9) | Matrix metalloproteinase-9 (MMP9) |
Type: | Enzyme |
Mol. Mass.: | 78452.28 |
Organism: | Homo sapiens (Human) |
Description: | P14780 |
Residue: | 707 |
Sequence: | MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEM
RGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHN
ITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYP
FDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRS
YSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYS
ACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYST
CTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMY
PMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSER
PTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYW
RFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRR
LDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLD
THDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED
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BDBM50246792 |
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n/a |
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Name | BDBM50246792 |
Synonyms: | CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-(methylcarbamoyl)-ethylcarbamoyl]-(5-methylhexanoyl)}-N-4-(4-bromophenyl)-benzenesulfonylhydrazide |
Type | Small organic molecule |
Emp. Form. | C32H36BrN5O5S |
Mol. Mass. | 682.628 |
SMILES | CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NNS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1 |r| |
Structure |
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