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TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
LigandBDBM50273601
Substrate/Competitorn/a
Meas. Tech.ChEMBL_537823 (CHEMBL989824)
IC50>50000±n/a nM
Citation Zheng, SKaur, GWang, HLi, MMacnaughtan, MYang, XReid, SPrestegard, JWang, BKe, H Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors. J Med Chem51:7673-88 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Name:High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:Enzyme
Mol. Mass.:55514.96
Organism:Homo sapiens (Human)
Description:Q13946
Residue:482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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BDBM50273601
n/a
NameBDBM50273601
Synonyms:4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin-3-ylbutan-2-one | CHEMBL457216
TypeSmall organic molecule
Emp. Form.C25H22N2O3
Mol. Mass.398.4538
SMILESCOc1cc(ccc1Oc1ccccn1)C(CC(C)=O)c1cnc2ccccc2c1
Structure
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