| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Ligand | BDBM50273601 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_537823 (CHEMBL989824) |
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| IC50 | >50000±n/a nM |
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| Citation |  Zheng, S; Kaur, G; Wang, H; Li, M; Macnaughtan, M; Yang, X; Reid, S; Prestegard, J; Wang, B; Ke, H Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors. J Med Chem51:7673-88 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55514.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13946 |
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| Residue: | 482 |
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| Sequence: | MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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| BDBM50273601 |
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| n/a |
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| Name | BDBM50273601 |
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| Synonyms: | 4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin-3-ylbutan-2-one | CHEMBL457216 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N2O3 |
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| Mol. Mass. | 398.4538 |
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| SMILES | COc1cc(ccc1Oc1ccccn1)C(CC(C)=O)c1cnc2ccccc2c1 |
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| Structure | 
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