Reaction Details |
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Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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Ligand | BDBM50273601 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_537824 (CHEMBL989825) |
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IC50 | >50000±n/a nM |
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Citation | Zheng, S; Kaur, G; Wang, H; Li, M; Macnaughtan, M; Yang, X; Reid, S; Prestegard, J; Wang, B; Ke, H Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors. J Med Chem51:7673-88 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Synonyms: | 3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A) |
Type: | Protein |
Mol. Mass.: | 68488.40 |
Organism: | Homo sapiens (Human) |
Description: | O76083 |
Residue: | 593 |
Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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BDBM50273601 |
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n/a |
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Name | BDBM50273601 |
Synonyms: | 4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin-3-ylbutan-2-one | CHEMBL457216 |
Type | Small organic molecule |
Emp. Form. | C25H22N2O3 |
Mol. Mass. | 398.4538 |
SMILES | COc1cc(ccc1Oc1ccccn1)C(CC(C)=O)c1cnc2ccccc2c1 |
Structure |
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