| Reaction Details |
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 | Report a problem with these data |
| Target | D(3) dopamine receptor |
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| Ligand | BDBM50273419 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_561955 (CHEMBL1010018) |
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| Ki | 89.3±n/a nM |
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| Citation |  Brown, DA; Kharkar, PS; Parrington, I; Reith, ME; Dutta, AK Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model. J Med Chem51:7806-19 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(3) dopamine receptor |
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| Name: | D(3) dopamine receptor |
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| Synonyms: | DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3 |
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| Type: | Protein |
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| Mol. Mass.: | 49540.58 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P19020 |
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| Residue: | 446 |
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| Sequence: | MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSI
CSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQ
QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLK
RYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGP
LQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV
NSALNPVIYTTFNVEFRKAFLKILSC
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| BDBM50273419 |
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| n/a |
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| Name | BDBM50273419 |
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| Synonyms: | (+)-(4aR,10aR)-trans-4-(2-(4-Phenylpiperazin-1-yl)ethyl)-1,2,3,4,4a,5,6,10b-octa-hydrobenzo[f]quinolin-7-ol | CHEMBL513931 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H33N3O |
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| Mol. Mass. | 391.549 |
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| SMILES | Oc1cccc2[C@H]3CCCN(CCN4CCN(CC4)c4ccccc4)[C@@H]3CCc12 |r| |
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| Structure | 
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