| Reaction Details |
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 | Report a problem with these data |
| Target | Phospholipase A2, membrane associated |
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| Ligand | BDBM50247034 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_557558 (CHEMBL955001) |
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| IC50 | 43700±n/a nM |
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| Citation |  Wei, D; Jiang, X; Zhou, L; Chen, J; Chen, Z; He, C; Yang, K; Liu, Y; Pei, J; Lai, L Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. J Med Chem51:7882-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phospholipase A2, membrane associated |
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| Name: | Phospholipase A2, membrane associated |
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| Synonyms: | GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A |
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| Type: | Hydrolase |
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| Mol. Mass.: | 16101.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification. |
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| Residue: | 144 |
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| Sequence: | MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
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| BDBM50247034 |
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| n/a |
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| Name | BDBM50247034 |
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| Synonyms: | 4-(4-Nitro-benzyl)-1-(2-oxo-2-phenyl-ethyl)-pyridinium; bromide | CHEMBL460497 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17N2O3 |
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| Mol. Mass. | 333.36 |
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| SMILES | [O-][N+](=O)c1ccc(Cc2cc[n+](CC(=O)c3ccccc3)cc2)cc1 |
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| Structure | 
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